Robohub.org
 

DNA testing chip delivers results in one hour, paves way for personalized drug treatments

by
04 April 2013



share this:
13-0022-r

Panasonic, together with the Belgium-based research institution IMEC, has developed a DNA testing chip that automates all stages of obtaining genetic information, including preprocessing.

This development is expected to enable personalized, tailor-made therapy to become widespread.

“This is the chip we’ve actually developed. As you can see, it’s less than half the size of a business card. It contains everything needed for testing DNA. Once a drop of blood is inserted, the chip completes the entire process, up to SNP detection.”

SNPs are variations in a single DNA base among individuals.

Detecting SNPs makes it possible to check whether genetically transmitted diseases are present, evaluate future risks, and identify genes related to illness.

“By investigating SNPs, we can determine that this drug will work for this person, or this drug will have severe side-effects on that person. Investigating SNPs enables tailor-made therapy. But with the current method, it has to be done in a specialized lab, so it actually takes three to four days. In the worst case, it takes a week from sending the sample to getting the result. Our equipment can determine a patient’s SNPs in just an hour after receiving the blood.”

Testing is done simply by injecting the blood and a chemical into the chip, and setting it in the testing system.

First of all, the blood and chemical are mixed. DNA is then extracted from the mixed solution. The regions containing SNPs are then cut out and amplified. DNA amplification uses technology called PCR, which cuts out the desired sections by varying the temperature. With the conventional method, this process took two hours.

“Through careful attention to thermal separation design, we’ve achieved high-speed PCR, where 30 temperature cycles are completed in nine minutes. We think this is one of the fastest PCR systems in the world.”

The amplified DNA is then sent through a micropump to a DNA filter. Here, the DNA is separated for each section length. Then, a newly developed electrochemical sensor identifies SNPs while the DNA is dissolved in the chemical.

“To implement this system on one chip, and make detection easy, the first thing we focused on was the actuators. This system requires a very small, powerful pump. In our case, we used a conductive polymer for the actuators. A feature of these actuators is they’re powerful, yet extremely compact. They can exert a pressure of up to 30MPa.”

“Ultimately, we’d like to make this system battery-powered. We think that would enable genetically modified foods to be tested while still in the warehouse.”



tags: ,


DigInfo TV is a Tokyo-based online video news platform dedicated to producing original coverage of cutting edge technology, research and products from Japan.
DigInfo TV is a Tokyo-based online video news platform dedicated to producing original coverage of cutting edge technology, research and products from Japan.





Related posts :



Robo-Insight #5

In this fifth edition, we are excited to feature robot progress in human-robot interaction, agile movement, enhanced training methods, soft robotics, brain surgery, medical navigation, and ecological research. 
25 September 2023, by

Soft robotic tool provides new ‘eyes’ in endovascular surgery

The magnetic device can help visualise and navigate complex and narrow spaces.

‘Brainless’ robot can navigate complex obstacles

Researchers who created a soft robot that could navigate simple mazes without human or computer direction have now built on that work, creating a “brainless” soft robot that can navigate more complex and dynamic environments.
21 September 2023, by

Battery-free origami microfliers from UW researchers offer a new bio-inspired future of flying machines

Researchers at the University of Washington present battery-free microfliers that can change shape in mid-air to vary their dispersal distance.

Virtual-reality tech is fast becoming more real

Touch sensations are improving to help sectors like healthcare and manufacturing, while other advances are being driven by the gaming industry.
16 September 2023, by

High-tech microscope with ML software for detecting malaria in returning travellers

Method not as accurate as human experts, but shows promise.
14 September 2023, by and





©2021 - ROBOTS Association


 












©2021 - ROBOTS Association